Endocrine Abstracts

Background: Selenium (Se) is a crucial micronutrient for thyroid gland homeostasis. Acting through iodothyronine deiodinases, it regulates thyroid hormones synthesis and by glutathione peroxidases removes harmful free radicals. The Se role in pathogenesis of autoimmune thyroiditis is currently under investigation. Se supplementation decreases antithyroid antibodies during pregnancy, may prevent from postpartum thyroiditis and is approved for treatment of mild Graves’ opht...

Background: Selenium (Se) sufficiency is beneficial for thyroid metabolism and pregnancy course due to its antioxidant and anti-inflammatory properties. As a part of selenoenzymes, it ameliorates autoimmune thyroid disease (AITD) progression in mothers and provides proper neurogenesis in fetuses. Despite lacking or conflicting recommendations for its supplementation in pregnancy, Se is used in a clinical setting, as a common constituent of multivitamin pregnancy diet supplemen...

Ghrelin is a peptide discovered in 1999 as the first natural growth hormone secretagogue. It also proved to be an essential regulator of metabolism increasing appetite, body weight and stimulating peristalsis. Thyroid plays an important role in the maintenance of energy balance. Thus, correlation between ghrelin and thyroid function is worth consideration. Previous studies suggested, that ghrelin production is increased in hypothyroidism and decreased in hyperthyroism. However...

Introduction: Subclinical hyperthyroidism (SH) affects about 1% of world human population at least. The diagnosis of this disease leans on the laboratory criteria only: decreased of TSH and normal FT3 and FT4 concentrations. SH increases mortality mostly due to cardiovascular diseases including overload of the heart and ventricular arrhythmia. These symptoms are anticipated by increasing of left ventricular walls thickness and its mass index.<p class=...

Background: Conventional management of Interferon-α-Induced Hyperthyroidism (IIH) with radioactive iodine (RAI) may be used when treatment with β blockers or antithyroid drugs (ATD), proves ineffective or is contraindicated.Case presentation: We present a 38-year-old woman who has been treated with combined pegylated interferon alpha (INF-α) and Ribavirin for chronic hepatitis C. Destructive thyrotoxicosis appeared after four months of con...